Ongoing projects

We study how different goblet cell subtypes produce mucus with distinct properties and how this diversity shapes barrier function in the intestine. Using single-cell sequencing, genetic mouse models, and advanced mucus characterization, we aim to pinpoint how changes in goblet cell composition contribute to disease.

Goblet Cell Heterogeneity and Mucus Function

Mucus Dysfunction in Ulcerative Colitis

Our work investigates how post-translational modifications such as glycosylation, crosslinking, and proteolysis of MUC2 drive mucus breakdown in ulcerative colitis. By integrating biochemistry and functional assays, we aim to identify molecular pathways that could be targeted to restore mucus barrier integrity.

To improve relevance of preclinical studies, we are mapping goblet cell diversity and mucus properties across human and murine colon. This atlas will guide the choice of experimental models and open the way for translational research and drug discovery in UC and related conditions.

Translational Models for Mucus-Associated Diseases

Physiological Functions of CLCA1

We are exploring the role of the mucus-associated protease CLCA1 in shaping mucus structure and maintaining intestinal homeostasis. These studies combine biochemistry, structural biology, and genetic models to uncover how CLCA1 contributes to health and disease.